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Prior to her retirement, O'Hartigan was involved in a number of trans civil rights and nondiscrimination campaigns in Oregon, Washington, and Minnesota, including successfully suing the state of Minnesota to cover the costs of sex reassignment surgery for low-income trans people, challenging transphobic policies at Seattle-area gay and lesbian organizations, and heavily influencing Portland's trans nondiscrimination legislation. In addition to her trans activism work, O'Hartigan published many articles in a variety of mainstream, gay and lesbian, trans, and feminist publications over the decades, worked as a typesetter at a number of publications, and founded and ran the Filisa Vistima Foundation, a Pacific Northwest transsexual advocacy and resource-linking organization. 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